Lazorthes 1982.

Study characteristics
Methods	Study design: Parallel‐group randomised trials Duration of trial: January 1979 to March 1980 Duration of follow‐up: 2 months Country of origin: France
Participants	Baseline characteristics Number randomised: 90 participants Number analysed: 90 participants Number eligible and included in this review: 60 Only a subset of the study patients was included in the meta‐analysis. Patients in study group O did not receive perioperative intravenous antibiotic prophylaxis and were therefore excluded from the meta‐analysis. Intervention: MBP+oAB Number of participants [n]: 30 Age [years; mean (SD)]: 64.8 (11.94) Gender [male/female; n]: 20/10 Control: MBP Number of participants [n]: 30 Age [years, mean (SD)]: 65.4 (10.21) Gender [male/female; n]: 14/16 Inclusion criteria  Elective colorectal surgery Exclusion criteria Quote:"Patients requiring colostomy alone* or having to undergo surgery for hemorrhagic rectocolitis, as well as patients who had received antibiotics for seven days prior to surgery, were excluded from the study." Baseline imbalances None
Interventions	Comparison Intervention: MBP+oAB + antibiotic administered intramuscularly (Group O + S´) Control: MBP (Group S) MBP Agent(s): magnesium sulfate and procedures such as enemas and low‐residue diet Dose per administration: ‐ Time(s) of intake: over three days preoperatively Route: oral/rectal Concomitant medications: ‐ oAB Agent(s): kanamycin and metronidazole Dose per administration: 1000 mg and 250 mg Time(s) of intake: Quote:"During the three days prior to surgery in four equally divided doses" Route: oral Concomitant medications: 2 mg/kg/KG gentamicin i.m. at the time of premedication Perioperative intravenous antibiotic prophylaxis Agent(s): cephradine Dose per administration: 2 g Time(s) of intake: During induction of surgery Adherence to regimen: ‐
Outcomes	Outcomes sought in review and reported in trial Mortality Length of hospital stay Outcomes sought but not reported in trial SSI Anastomotic leakage Postoperative complications (mild D/C I + II or severe D/C III+IV) Incidence of postoperative ileus Side effects of Intervention(s) Outcomes reported in trial but not used in review Wound abscesses Septicaemia Fistula Abdominal abscesses Septic deaths
Notes	Source of funding: ‐ Conflicts of interest: ‐ Ethics approval: ‐ Informed consent: ‐ Clinical trials registration: ‐ Sample size calculation: ‐