NCT03563586.

Study name	Mechanical Bowel Preparation With or Without Oral Antibiotics for Colorectal Cancer Surgery (MECCA)
Methods	Study type: interventional (Clinical Trial) Study design Allocation: randomised Interventional model: Sequential Assignment Masking: triple (Care Provider, Investigator, Outcomes Assessor) Primary purpose: prevention
Participants	Condition or disease: Antibiotic, Bowel Cancer, Colorectal Cancer, Surgical Site Infection Inclusion criteria Scheduled colorectal cancer surgery Exclusion criteria Emergency surgery Obstructive and perforated cancer Intolerance to bowel preparation regimen Allergies to orally administered antibiotics Target sample size: 105
Interventions	Treatment arms Bowel Preparation plus antibiotics: preoperative oral antibiotic therapy with rifaximin 400 mg plus metronidazole 500 mg the day prior to surgery at 2:00, 3:00 and 10:00 pm, with mechanical bowel preparation (2 vials sodium phospate 45 mL at 1:00 and 7:00 pm) Bowel preparation: preoperative mechanical bowel preparation (2 vials sodium phospate 45ml at 1:00 and 7:00 pm)
Outcomes	Primary outcome Surgical Site Infections [Time Frame: 30 days] Secondary outcomes Anastomotic leaks [Time Frame: 30 days] Other surgical and non‐surgical complications [Time Frame: 30 days] Hospital length of stay [Time Frame: 30 days] Readmission rate [Time Frame: 30 days] Patients' preparation tolerance [Time Frame: 30 days] Preparation regimens side effects [Time Frame: 30 days] Time to beginning of adjuvant treatment for colorectal cancer [Time Frame: 60 days]
Starting date	Date of registration: June 9, 2018 Study Start Date: April 1, 2018 Estimated Primary Completion Date: April 1, 2021 Recruitment Status: Recruiting (Last Update Posted: September 11, 2020)
Contact information	Contact person: George Theodoropoulos Affiliation: National and Kapodistrian University of Athens Country of origin: Greece
Notes	Ethics approval: ‐ Source of funding: National and Kapodistrian University of Athens