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. 2023 Feb 7;2023(2):CD014909. doi: 10.1002/14651858.CD014909.pub2

Tagliaferri 2020.

Study name Combined mechanical and oral antibiotic bowel preparation versus oral antibiotics alone for the reduction of surgical site infection following elective colorectal resection: Interim analysis
Methods Study type:
Study design: randomised controlled trial
Participants Condition or disease: Elective colon resection
Inclusion criteria
All patients over 18 years of age undergoing elective colon resections were included in the study
Exclusion criteria
‐
Target sample size:
Interventions Treatment arms
  • Intervention: Neomycin and Metronidazole for antibiotic preparation with polyethylene glycol.

  • Control: Neomycin and Metronidazole for antibiotic preparation without polyethylene glycol.

Outcomes Primary outcomes
  • Superficial and deep SSI

  • Anastomotic leak


Secondary outcomes
  • Clostridium difficile infection

  • Ileus

  • Cardiopulmonary complications

  • Urinary tract infectionLength of stay

  • Mortality

Starting date Date of registration:
Study Start Date:
Estimated Primary Completion Date:
Recruitment Status:
Contact information Contact person: A. R. Tagliaferri
Affiliation: ‐
Country of origin: USA
Notes Ethics approval:
Source of funding:

BMI: body mass index; IV: intravenous; ECOG: Eastern Cooperative Oncology Group; IBD: irritable bowel disease; MRI: magnetic resonance imaging; RCT: randomised controlled trial; SSI: surgical site infections