Appendix 1—table 1. Levels of spurious signal of concordant evolution, inferred in the simulated dataset with no epistasis by four variants of the method.
Number of pairs, detected under p-value threshold 10-4, and estimated FDR for this threshold are shown.
| Model | #FP | min p-value | Maximal FDR threshold for#FP = 0 | |
|---|---|---|---|---|
| consider alleles | shuffle mutations in fgr. only | 2 | <1e-4 | 0,25 |
| shuffle mutations both in bgr. and fgr. | 3 | <1e-4 | 0,15 | |
| ignore alleles | shuffle mutations in fgr. only | 4 | <1e-4 | 0,11 |
| shuffle mutations both in bgr. and fgr. | 24 | <1e-4 | 0,02 | |