Appendix 1—table 11. Coordinated episodic selection in discordantly evolving pairs predicted for the phylogeny reconstructed by IQ-TREE.

Z-scores < 0 and upper p-values after Benjamini-Hochberg adjustment < 0.05 indicate clustering of nonconsecutive mutations; z-scores > 0 and lower p-values after Benjamini-Hochberg adjustment < 0.05 indicate that nonconsecutive mutations tend to avoid each other. For site pairs with z-scores < 0, discordant evolution cannot be explained without negative epistatic interaction between the sites.

site 1	site 2	#nonseq. pairs	zscore	lower pvalue	upper pvalue	lower pvalue adj.	upper pvalue adj.
69	614	2875	2,27	0,015	0,985	0,06	1
222	501	17114	–0,861	0,795	0,205	0,995	0,369
440	681	10559	–2,229	0,995	0,005	0,995	0,045
501	675	18907	–2,39	0,9875	0,0125	0,995	0,0563
501	677	30478	–1,463	0,925	0,075	0,995	0,1856
570	614	5813	1,738	0,0425	0,9575	0,0956	1
614	653	1856	2,944	0,0025	1	0,0225	1
614	982	4913	2,226	0,02	0,98	0,06	1
681	1176	9599	–1,326	0,9175	0,0825	0,995	0,1856