Appendix 1—table 13. Coordinated episodic selection in discordantly evolving pairs predicted for the phylogeny reconstructed by USHER.

Z-scores < 0 and upper p-values after Benjamini-Hochberg adjustment < 0.05 indicate clustering of nonconsecutive mutations; z-scores > 0 and lower p-values after Benjamini-Hochberg adjustment < 0.05 indicate that nonconsecutive mutations tend to avoid each other. For site pairs with z-scores < 0, discordant evolution cannot be explained without negative epistatic interaction between the sites.

site 1	site 2	#nonseq. pairs	zscore	lower pvalue	upper pvalue	lower pvalue adj.	upper pvalue adj.
18	681	34644,5	–1,979	0,9725	0,0275	0,98	0,2
222	501	20756	0,222	0,3825	0,6175	0,68	1
439	501	7667	–1,207	0,8875	0,1125	0,98	0,45
440	501	11220	0,422	0,325	0,675	0,665	1
440	681	13859	–0,599	0,7375	0,2625	0,98	0,6629
484	982	21249	4,304	0,0025	1	0,0133	1
501	675	22065	–1,868	0,9625	0,0375	0,98	0,2
501	677	36276	–0,526	0,71	0,29	0,98	0,6629
570	677	22309	4,782	0,0025	1	0,0133	1
614	653	2273	1,739	0,05	0,95	0,16	1
675	716	13924	–0,731	0,7725	0,2275	0,98	0,6629
675	1118	13452	0,417	0,3325	0,6675	0,665	1
677	681	44811	–2,043	0,98	0,02	0,98	0,2
677	716	22891	0,604	0,265	0,735	0,665	1
677	982	17847	3,543	0,0025	1	0,0133	1
677	1118	22115	1,869	0,0425	0,9575	0,16	1