Appendix 1—table 6. Predicted discordantly evolving pairs for the simulated data with positively and negatively epistatically interacting sites.

See legend for Appendix 1—table 4. The ‘p-value’ column contains the lower p-values.

site1	site2	p-value	epistat	#consec. pairs of mut.	#mut. in consec. pairs in site1	#mut. in consec. pairs in site2	#mut. in site1	#mut. in site2	exp. epistat	SE
16	50	<1e-4	5,72	85,5	47	83	108	178	10,51	1,48
17	96	1e-4	7,44	93,5	54	90	109	192	12,92	1,70
23	24	<1e-4	8,27	70,5	51	68	137	129	13,70	1,65
25	26	<1e-4	6,13	73,5	37	74	139	121	10,84	1,46
26	95	1e-4	6,94	91,5	52	94	121	179	12,18	1,60
27	28	<1e-4	5,90	76	42	73	168	149	13,90	1,82
33	34	1e-4	4,70	48,5	37	45	117	136	8,55	1,30
35	36	<1e-4	5,47	59,5	39	55	150	127	10,81	1,51
37	38	<1e-4	4,10	44,5	32	41	113	146	8,93	1,39
39	40	<1e-4	4,97	61,5	37	59	115	142	11,11	1,47
39	47	<1e-4	7,27	86,5	54	84	115	166	13,09	1,66