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. 2023 Feb 8:1–11. Online ahead of print. doi: 10.1038/s41577-023-00835-3

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Fig. 1 — a, Cartoon illustrating cancer cell antigen presentation to a naive T cell; T cell activation and expansion and effector T cell engagement of the cancer cell. b, Antigen recognition by conventional T cells through the interaction of the αβ T cell receptor (TCR) heterodimer with peptide antigen presented by an MHC class I molecule. c, Crystal structure of the affinity-enhanced A3A TCR engaging with melanoma-associated antigen 3 (MAGE-A3)-derived peptide presented by HLA-A*01 (ref. ¹⁰¹) (generated with data from ref. ¹⁰¹ and visualized with PyMOL (see Related links)).