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. 2023 Feb 8;43(6):993–1007. doi: 10.1523/JNEUROSCI.1672-22.2022

Figure 11.

Figure 11.

Neuronal mechanism driving the contrast shift in light/dark visual dominance. a, Simulated ON and OFF contrast–response functions with different contrast sensitivity (ON > OFF) and maximum response (OFF > ON) accurately replicate the data from ON-OFF perimetry. Low contrasts drive stronger cortical responses for light than dark stimuli, whereas high contrasts drive stronger cortical responses for dark than light stimuli. b, Light/dark ratios calculated from a division of the contrast response functions shown in b closely match our measurements in human vision for missed targets averaged across 5° to 30° eccentricities. ON/OFF fitting parameters used to generate Naka–Rushton functions in a: C50, 15%/20%; exponent, 1.5/1.8; Rmax, 1/2. These ON-OFF parameter ratios are similar to those measured in cat visual cortex, cat visual thalamus, human visual cortex, and natural scenes at midgray backgrounds (Kremkow et al., 2014; Rahimi-Nasrabadi et al., 2021).