Table 2.
Univariate Analysis of Demographic and Clinical Variables between Patients with and without Infusion Reaction (IR).
| Without IR
(n = 32) |
With IR
(n = 25) |
P-value | |
|---|---|---|---|
| Patient characteristics | |||
| Age, years | 52 (28-84) | 64 (33-83) | 0.16 |
| Height, m | 1.56 (1.45-1.68) | 1.56 (1.46-1.70) | 0.91 |
| Body weight, kg | 55 (41-97) | 50 (40-100) | 0.092 |
| BMI, kg/m2 | 22.4 (17-37) | 20.3 (17-40) | 0.058 |
| History of allergy, n | 16 (50%) | 10 (40%) | 0.59 |
| History of smoking, n | 8 (25%) | 11 (44%) | 0.30 |
| History of alcohol consumption, n | 15 (47%) | 9 (36%) | 0.43 |
| Estrogen receptor, n | |||
| positive | 20 (63%) | 16 (64%) | 1.0 |
| negative | 12 (38%) | 9 (36%) | |
| Treatment settings, n | |||
| pre-operative | 11 (34%) | 9 (36%) | 0.031* |
| post-operative | 2 (6%) | 8 (32%) | |
| recurrent | 12 (38%) | 3 (12%) | |
| stage IV | 7 (22%) | 5 (20%) | |
| Anti-cancer drug administration within 3 months before Pmab, n | |||
| anthracycine | 13 (41%) | 17 (68%) | 0.061 |
| none or other than anthracycline | 19 (59%) | 8 (32%) | |
| Blood test data | |||
| WBC, /μL | 5200 (2600-15300) | 5000 (1700-15700) | 0.57 |
| NTR, /μL | 3400 (1600-12900) | 3500 (850-13500) | 0.63 |
| LYM, /μL | 870 (370-2290) | 860 (200-2340) | 0.48 |
| MON, /μL | 300 (160-980) | 320 (100-1600) | 0.76 |
| RBC, 104/μL | 400 (300-500) | 350 (210-480) | <0.001 |
| Hb, g/dL | 12.0 (9.6-14) | 10.8 (6.5-14) | 0.0011 |
| Hct, % | 36 (30-44) | 32 (19-42) | <0.001 |
| MCV, fL | 93 (81-100) | 93 (79-99) | 0.61 |
| MCH, pg | 31 (24-42) | 31 (26-35) | 0.49 |
| MCHC, % | 33 (30-35) | 34 (32-35) | 0.21 |
| PLT, 104/μL | 27 (9.5-52) | 26 (4.6-55) | 0.69 |
| NLR | 3.9 (1.1-14) | 4.0 (1.3-26) | 0.86 |
| MLR | 0.36 (0.14-1.3) | 0.49 (0.11-1.3) | 0.37 |
| PLR | 300 (110-1110) | 300 (140-1000) | 0.88 |
| AST, U/L | 21 (10-53) | 21 (11-420) | 0.74 |
| ALT, U/L | 17 (5-77) | 16 (8-91) | 0.64 |
| ALP, U/L | 230 (60-650) | 240 (95-2900) | 0.50 |
| γ-GTP, U/L | 28 (18-150) | 22 (15-1400) | 0.17 |
| LDH, U/L | 220 (160-380) | 210 (140-1400) | 1.0 |
| TP, g/dL | 6.9 (6.3-7.5) | 6.8 (5.8-7.9) | 0.27 |
| Alb, g/dL | 4.1 (2.9-4.7) | 3.9 (2.4-4.5) | 0.11 |
| BUN, mg/dL | 12 (7.0-55) | 13 (6.1-21) | 0.55 |
| Cre, mg/dL | 0.59 (0.40-1.80) | 0.56 (0.41-0.81) | 0.81 |
| CRP, mg/dL | 0.090 (0-3.9) | 0.070 (0-5.2) | 0.52 |
Data are median value (range) or n (%).
*Only the P-value for post-operative vs. recurrent is shown.
BMI, body mass index; WBC, white blood cell; NTR, neutrophil; LYM, lymphocyte; MON, monocyte; RBC, red blood cell; Hb, hemoglobin; Hct, hematocrit; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, Mean Corpuscular Hemoglobin Concentration; Plt, platelet; NLR, neutrophil-to-lymphocyte ratio; MLR, monocyte-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio; AST, aspartate aminotransferase; ALT, alanine aminotransferase; ALP, alkaline phosphatase; γ-GTP, γ-glutamyl transpeptidase; LDH, lactate dehydrogenase; TP, total protein; Alb, albumin; BUN, blood urea nitrogen; Cre, creatinine; CRP, C-reactive protein