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. 2022 Oct 24;28(2):919–930. doi: 10.1038/s41380-022-01841-y

Fig. 4. FMT from hippocampal NLRP3-downregulated mice induced depressive-like behavior in recipient mice.

Fig. 4

a Experimental design for FMT from hippocampal NLRP3-downregulated mice. b Time in the central area of the OFT. c Time spent in the open arms of the EPM. d Immobility time in the FST. e Immobility time in the TST. f Sucrose preference in the SPT. g The dynamic motion state in the FST. h Representative tracks of recipient mice in the OFT. i Representative tracks of recipient mice in the EPM. j PCoA plot showing unweighted UniFrac distances among recipient mice. k Difference in α-diversity among recipient mice. l Barplots showing the relative abundance of the gut microbiota at the family and genus levels. m Heatmap showing the distribution trends of species abundance in each sample. n Western blot showing the expression of tight junction proteins in ileal tissue. o Intestinal permeability was detected by FD4 gavage. Data are expressed as the mean ± SD, n = 10. *p < 0.05, **p < 0.01, ***p < 0.001.