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. 2022 Oct 24;28(2):919–930. doi: 10.1038/s41380-022-01841-y

Fig. 5. FMT from hippocampal NLRP3-downregulated mice induced systemic inflammation in recipient mice.

Fig. 5

a Serum LPS and inflammatory cytokine concentrations in recipient mice detected by ELISA and Luminex assays. b Western blot showing the expression of Iba1 and GFAP in the hippocampus of recipient mice. c–e IF of Iba1/GFAP and Sholl analysis showing the number, morphology, and length of microglia/astrocytes in the hippocampus (scale bar = 100 μm). f Western blot showing the expression of NLRP3, caspase-1, ASC, IL-18 and NF-κB. g, h Western blot and IF showing the expression of synaptic proteins in the hippocampus (scale bar = 100 μm). Data are expressed as the mean ± SD, n = 10. *p < 0.05, **p < 0.01, ***p < 0.001.