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. 2022 Oct 17;28(2):810–821. doi: 10.1038/s41380-022-01822-1

Fig. 5. CNTNAP2-dependent cell types and the specific processes in which they are involved in CNTNAP2-deficient ASD patient-derived brain organoids.

Fig. 5

a UMAP visualization of the 5 representative cell types identified in the forebrain organoid DPal cells. See color legend for the cell type assignment. b Heatmap showing the significance of cellular processes enriched with DEPs, DEGs, and cell-type-specific DEGs identified in the mouse proteome results, ASD patient integration results, and ASD organoid results. c Expression of CNTNAP2 in ASD and healthy organoid DPal cells. d Dot plot showing cell-type-specific CNTNAP2 expression. The dot size and color represent the proportion of CNTNAP2-expressing cells and average CNTNAP2 expression per cell-type cluster, respectively. e Functional protein association network of genes shown in both Cntnap2 KO DEP and Ex-specific DEG. The node color represents the expressional difference between ASD and healthy organoids in Ex cells. The edge thickness represents the STRING interaction score.