Table 1.
Summary of cohorts used in this study.
| Cohorts 1 and 2 | Cohort 3 (PsychArray) | Cohort 4 (Omni1Mc) | Cohort 5 | ||||
|---|---|---|---|---|---|---|---|
| Affection status | Casesa | Cases | Controlsb | Cases | Controlsb | Cases | Controlsb |
| Case phenotype | Suicide death | Suicidal attempts | Suicidal attempts | Suicidal attempts | |||
| N | 3765 | 183 | 1199 | 268 | 780 | 4098 | 247,898 |
| Cases with linked demographic data, N | 3426 | 183 | 1199 | 268 | 780 | 4098 | 247,898 |
| Cases with linked demographic data and EHR, N | 2981 | N/A | N/A | N/A | N/A | 4098 | 247,898 |
| Demographic information | |||||||
| Female, n (%) | 743 (21.7) | 95 (51.9) | 612 (51.0) | 142 (53.0) | 435 (55.8) | 3525 (86.0) | 138,666 (55.9) |
| Age, mean (SD) | 41.0 (17.2) | 47.1 (13.0) | 44.3 (14.2) | 41.2 (11.8) | 43.6 (12.5) | 56.6 (17.8) | 59.6 (17.7) |
| Clinical characteristics, n (%) | |||||||
| Bipolar disorder | 321 (10.8) | 91 (34.0) | 223 (28.6) | 257 (6.3) | 3428 (1.4) | ||
| Broad bipolar spectrum illness | 450 (15.1) | 295 (7.2) | 4130 (1.7) | ||||
| MDD | 927 (31.1) | 87 (47.3) | 492 (41.0) | 93 (34.7) | 355 (45.5) | 1020 (24.9) | 20,691 (8.3) |
| Broad depression | 1568 (52.6) | 1141 (27.8) | 24,379 (9.8) | ||||
| Anxiety | 747 (25.1) | 844 (20.6) | 17,576 (7.1) | ||||
| Schizophrenia | 117 (3.9) | 53 (28.8) | 579 (48.3) | 20 (7.5) | 87 (11.2) | 222 (5.4) | 2634 (1.1) |
| Psychosis | 295 (9.9) | 673 (16.4) | 13,185 (5.3) | ||||
| Pain | 1636 (54.9) | 40 (1.0) | 1012 (0.4) | ||||
| Sleep problems | 822 (27.6) | 328 (8.0) | 9312 (3.8) | ||||
| SUD | 1513 (50.8) | 739 (18.0) | 13,895 (5.6) | ||||
| SLE | 283 (9.5) | – | – | ||||
| Suicidal ideation | 560 (18.8) | – | – | ||||
| Adult maltreatment | 7 (0.2) | – | – | ||||
| Childhood maltreatment | 15 (0.5) | – | – | ||||
| Any mental health | 2142 (71.9) | 2378 (58.0) | 73,576 (29.7) | ||||
| Diabetes | 278 (9.3) | ||||||
| Asthma | 359 (12.0) | ||||||
| Schizoaffective disorder | 43 (23.5) | 128 (10.7) | 64 (23.9) | 115 4.7) | |||
Specifically, cohorts 1 and 2 are used for suicide death (SD) GWAS meta-analysis, and cohorts 1–5 are used for suicidal behavior (SB) GWAS meta-analysis.
aThe controls for cohort 1 are Coriell controls screened for psychiatric medical and family history (n = 804), while the controls for cohort 2 are IAMDGC controls not screened for suicide attempt (n = 5768).
bThe controls for cohorts 3 and 4 are psychiatric controls within the same studies.
cUsing the overlapping markers between Omni1M-Duo and Omni5M.