Table 2. Changes in parameters at 3 months after non- surgical periodontal therapy of periodontitis group.
| Variables | Baseline (n=40) | After therapy (n=40) | P values |
|---|---|---|---|
| Periodontal clinical parameters | |||
| PD (mm) | 4.42 ± 0.76 | 3.06 ± 0.49 | <0.001* |
| BI | 3.44 ± 0.62 | 1.83 ± 0.64 | <0.001* |
| Inflammatory markers | |||
| WBC (109/L) | 6.40 ± 1.40 | 5.62 ± 1.50 | 0.002** |
| hs-CRP (mg/L) | 1.33 ± 1.75 | 0.59 ± 0.48 | 0.025* |
| ESR | 8.46 ± 4.22 | 6.24 ± 3.87 | 0.116 |
| IL-6 (pg/ml) | 19.05 ± 8.55 | 14.76 ± 5.43 | 0.046* |
| Anemia-related indicators | |||
| RBC (1012/L) | 4.60 ± 0.45 | 4.67 ± 0.50 | 0.569 |
| HGB (g/L) | 129.40 ± 13.08 | 139.50 ± 14.85 | 0.002** |
| HCT (L/L) | 0.40 ± 0.03 | 0.42 ± 0.04 | 0.007** |
| MCV (fL) | 88.34 ± 4.55 | 88.61 ± 4.78 | 0.627 |
| MCH (pg/cell) | 29.98 ± 2.09 | 29.90 ± 2.25 | 0.872 |
| MCHC (g/L) | 339.00 ± 11.37 | 337.6 ± 9.01 | 0.594 |
| Iron metabolism markers | |||
| Hepcidin (ng/ml) | 40.25 ± 19.88 | 22.90 ± 24.61 | 0.034* |
| Fe (μmol/L) | 13.16 ± 4.54 | 15.97 ± 7.02 | 0.023* |
| Ferritin (ng/mL) | 153.8 ± 106.5 | 96.50 ± 70.10 | 0.024* |
| Transferrin (mg/dL) | 252.2 ± 54.47 | 283.2 ± 55.82 | 0.021* |
| TS (%) | 27.63 ± 7.75 | 29.17 ± 11.16 | 0.448 |
| TIBC (μmol/L) | 50.14 ± 10.19 | 55.03 ± 11.73 | 0.032* |
Abbreviations: AL, attachment loss; BI, bleeding index; HCT, hematocrit; HGB, hemoglobin; hs-CRP, high-sensitivity C-reactive protein; IL-6, interleukin-6; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; MCV, mean corpuscular volume; PD, probing depth; RBC, red blood cell; TIBC, total iron binding capacity; TS, transferrin saturation; WBC, white blood cell. Data are presented as mean ± SD/N. Between-group comparisons were performed using t-test, Chi-square test, or Mann–Whitney U-test; *P<0.05, **P<0.01, ***P<0.001.