Figure 3.

Immunoglobulin secretion and class switch under JAK inhibition. (A): Immunoglobulins measured by ELISA in supernatants of 3 experiments with triplicates each. Data depicted as floating bars (min to max) with line at mean. ANOVA with Dunnett’s multiple comparisons test as follow-up test, *p < 0.05, **p < 0.005. (B): Expression of the class-switch mediating enzyme AID under JAK inhibition with baricitinib measured by qPCR. Data from 4 experiments depicted relative to B cell housekeeping gene RPLPO. ANOVA with Dunnett’s multiple comparisons test, *p < 0.05.