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JAK inhibition leads to altered cytokine secretion profile. Secretion of IL-10, IL-6, IL-2, TNF-α, TNF-ß (LT-α), APRIL, BAFF, and CD40L was measured in supernatants of in-vitro B cell culture by cytokine multiplex assay on day 1, 2, and 3 during treatment with Tofacitinib, Baricitinib or Filgotinib. Data depicted as floating bars (min to max) with line at mean.
