Table 2.
Factors affecting lung metastasis-free survival (LMFS) among osteosarcoma patients (N = 55)
| N | Lung metastasis-free survival (LMFS) | Testa | p value | |||
|---|---|---|---|---|---|---|
| Mean 95% CI), months | 5-year LMFS | 10-year LMFS | ||||
| All patients | 55 | 167.1 (146.5–187.7) | 79.1% | 79.1% | – | – |
| Sex | ||||||
| Male | 30 | 175.1 (49.0–201.2) | 83.4% | 83.4% | 0.889 | 0.346 |
| Female | 25 | 151.1 (121.2–180.9) | 74.7% | 74.7% | ||
| Age group (year) | ||||||
| < 18 | 33 | 139.7 (115.3–164.1) | 75.1% | 75.1% | 0.582 | 0.445 |
| ≥ 18 | 22 | 177.3 (149.4–205.2) | 84.8% | 84.8% | ||
| Length resected (cm) | ||||||
| ≤ 15 | 31 | 178.9 (155.9–201.9) | 86.2% | 86.2% | 1.313 | 0.252 |
| > 15 | 24 | 131.3 (100.2–162.5) | 68.8% | 68.8% | ||
| Cement used | ||||||
| No | 19 | 130.4 (109.9–150.9) | 86.8% | 86.8% | 0.848 | 0.357 |
| Yes | 36 | 160.6 (134.2–186.9) | 75.4% | 75.4% | ||
| Closure | ||||||
| Uneventful | 49 | 162.3 (139.4–185.2) | 76.4% | 76.4% | 1.439 | 0.230 |
| Tight | 6 | 149.0 | 100% | 100% | ||
| Operative time (h) | ||||||
| ≤ 4 | 33 | 191.5 (174.6–208.3) | 92.9% | 92.9% | 8.297 | 0.004 |
| > 4 | 22 | 118.9 (85.2–152.8) | 59.7% | 59.7% | ||
| Chemotherapy | ||||||
| No | 3 | 157.0 | 100% | 100% | 0.752 | 0.386 |
| Yes | 52 | 164.5 (142.7–186.4) | 77.7% | 77.7% | ||
| Tumor necrosis | ||||||
| < 90% | 16 | 156.3 (124.4–188.3) | 84.4% | 84.4% | 0.284 | 0.594 |
| ≥ 90% | 36 | 160.5 134.1–186.9) | 75.3% | 75.3% | ||
| Overall complications | ||||||
| Absent | 18 | 115.8 (89.8–141.8) | 76.2% | 76.2% | 0.006 | 0.937 |
| Present | 37 | 167.6 (143.3–191.9) | 79.7% | 79.7% | ||
| Type 1 complication | ||||||
| Absent | 51 | 167.3 (145.6–188.9) | 79.2% | 79.2% | 0.065 | 0.799 |
| Present | 4 | 99.5 (57.9–141.1) | 75% | 75% | ||
| Type 2 complication | ||||||
| Absent | 47 | 164.3 141.1–187.5) | 77.4% | 77.4% | 0.234 | 0.629 |
| Present | 8 | 172.3 (132.4–212.1) | 87.5% | 87.5% | ||
| Type 3 complication | ||||||
| Absent | 43 | 158.8 (136.8–180.8) | 79.2% | 79.2% | 0.188 | 0.665 |
| Present | 12 | 173.4 (135.0–211.8) | 81.8% | 81.8% | ||
| Type 4 complication | ||||||
| Absent | 41 | 158.4 (132.3–184.4) | 74% | 74% | 1.512 | 0.219 |
| Present | 14 | 147.0 (128.1–165.9) | 92.9% | 92.9% | ||
| Type 5 complication | ||||||
| Absent | 52 | 168.8 (148.0–189.6) | 80% | 80% | 0.958 | 0.328 |
| Present | 3 | 70.0 (30.0–110.0) | 66.7% | 66.7% | ||
Bold value indicates significant at p < 0.05
Categorical variables were expressed as percentage; continuous variables were expressed as mean (95% CI)
aLog-rank test