Fig. 2.

miR-767 expression in exosomes of senescent endothelial cells and regulates senescence in fibroblasts. A Expression of miR-767 in skin fibroblasts by qRT-PCR. B Expressions of miR-767 in vascular endothelial cells by qRT-PCR. C Expression of miR-767 in skin fibroblasts after co-cultured with senescent endothelial cells by qRT-PCR. D Exosomes derived from vascular endothelial cells were observed by ultraelectron microscopy. E Expression of miR-767 in exosomes derived from senescent vascular endothelial cells by qRT-PCR. F SA-β-gal staining and Hoechst staining of skin fibroblasts with senescent vascular endothelial cells derived exosomes (100 ×). G Expression of miR-767 after transfection with miR-767 mimic and miR-767 inhibitor in skin fibroblasts by qRT-PCR. H The ratio of positive cells in skin fibroblasts after transfection miR-767 mimic was detected by SA-β-gal staining (100 ×). I The ratio of positive cells in skin fibroblasts after transfection miR-767 inhibitor + D-gal was detected by SA-β-gal staining and Hoechst staining (100 ×)