Table 4.
Cross table comparing current staging of sentinel node micrometastatic disease and the new nodal risk score, stratified by primary tumor AJCC stage, in accordance with the current AJCC stage III classification table
| N | pT1b-pT2a [n = 776] | pT2b-pT3a [n = 299] | pT3b-pT4a [n = 190] | pT4b [n = 112] | Test statistic | ||
|---|---|---|---|---|---|---|---|
| SN status | Positive | 1377 | 83 (10.7) | 55 (18.4) | 55 (28.9) | 45 (40.2) | χ2(9) = 82.96, p < 0.001a |
| Stageb | N0 | 1377 | 693 (89.3) | 244 (81.6) | 135 (71.1) | 67 (59.8) | χ2(9) = 86.79, p < 0.001a |
| N1 | 60 (7.7) | 38 (12.7) | 38 (20.0) | 30 (26.8) | |||
| N2 | 23 (3.0) | 15 (5.0) | 15 (7.9) | 13 (11.6) | |||
| N3 | 0 (0.0) | 2 (0.7) | 2 (1.1) | 2 (1.8) | |||
| AJCC IIIb | IIIA | 238 | 83 (100.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | χ2(9) = 468.79, p < 0.001a |
| IIIB | 0 (0.0) | 53 (96.4) | 0 (0.0) | 0 (0.0) | |||
| IIIC | 0 (0.0) | 2 (3.6) | 55 (100.0) | 43 (95.6) | |||
| IIID | 0 (0.0) | 0 (0.0) | 0 (0.0) | 2 (4.4) | |||
| New nodal risk scorec | N0 | 1377 | 693 (89.3) | 244 (81.6) | 135 (71.1) | 67 (59.8) | χ2(9) = 155.90, p < 0.001a |
| Low | 27 (3.5) | 16 (5.4) | 10 (5.3) | 0 (0.0) | |||
| Mid | 49 (6.3) | 31 (10.4) | 35 (18.4) | 24 (21.4) | |||
| High | 7 (0.9) | 8 (2.7) | 10 (5.3) | 21 (18.8) | |||
Data are expressed as n (%)
N indicates the number of non-missing values
aPearson (degrees of freedom)
bAJCC 8th edition
cNew nodal risk score is categorized as follows: low-risk = MTDS ≤0.7 mm/ECS absent; intermediate-risk = MTDS >0.7 mm/ECS absent; high-risk = ECS identified with any MTDS
SN sentinel node, AJCC III final AJCC stage after a positive SN biopsy, AJCC American Joint Committee on Cancer, MTDS maximum tumor deposit size, ECS extracapsular spread