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. 2022 Sep 10;26(1):193–196. doi: 10.1007/s10456-022-09855-4

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Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Suppression of the integrated signal pathways with the combination treatment in the liver. Most positive staining of VEGF (a), HIF-1α (b), p-ERK (c) and c-Fos (d) visualized by IHC were observed in the TAA group. Consistently, VEGF (e), HIF-1α (f) and c-Fos (g) mRNA and protein (h) and p-ERK protein (h) in the TAA group were the highest among three groups. *p < 0.05 versus control group; ^#p < 0.05 versus TAA group