Table 1.
Protein code | Gene | Log2 fold change | p.mod | Protein name |
---|---|---|---|---|
O15263 | DEFB4A | 10.96 | 0.00 | Beta-defensin 4A |
Q9NX55 | HYPK | 1.37 | 0.04 | Huntingtin-interacting protein K |
P01833 | PIGR | 1.28 | 0.03 | Polymeric immunoglobulin receptor |
O95861 | BPNT1 | 1.03 | 0.04 | 3'(2'),5'-bisphosphate nucleotidase 1 |
P59666 | DEFA1/3 | 1.01 | 0.04 | Neutrophil defensin 3 |
Q96CX2 | KCTD12 | 0.94 | 0.01 | BTB/POZ domain-containing protein KCTD12 |
O43920 | NDUFS5 | 0.89 | 0.03 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 |
P42330 | AKR1C3 | − 1.04 | 0.02 | Aldo–keto reductase family 1 member C3 |
Q92878 | RAD50 | − 1.07 | 0.01 | DNA repair protein RAD50 |
Q15046 | KARS | − 1.10 | 0.04 | Lysine–tRNA ligase |
P02794 | FTH1 | − 1.12 | 0.02 | Ferritin heavy chain |
P81605 | DCD | − 1.13 | 0.02 | Dermcidin |
P14927 | UQCRB | − 1.16 | 0.04 | Cytochrome b-c1 complex subunit 7 |
Q9NWH9 | SLTM | − 1.16 | 0.00 | SAFB-like transcription modulator |
P55786 | NPEPPS | − 1.24 | 0.01 | Puromycin-sensitive aminopeptidase |
P62841 | RPS15 | − 1.24 | 0.01 | 40S ribosomal protein S15 |
P38919 | E1F4A3 | − 1.36 | 0.05 | Eukaryotic initiation factor 4A-III |
P46937 | YAP1 | − 1.43 | 0.01 | Transcriptional coactivator YAP1 |
Q15417 | CNN3 | − 1.72 | 0.01 | Calponin-3 |
P35527 | KRT9 | − 2.34 | 0.02 | Keratin, type I cytoskeletal 9 |
HaCaT cell monolayers were treated with 0.5 μg/ml HBD2, or vehicle control, in serum free media for 48 h before supernatants were collected, centrifuged at 3000 rpm for 5 min, and stored at -80 °C prior to analysis; n = 5 per condition. Log fold changes and p values were generated using LIMMA pathway43. Table shows proteins with the greatest differences in detection levels between control and HBD2 treated conditions, listed by fold change, largest to smallest, with Uniprot protein code, gene code, fold change, p.mod value, protein name and brief description of function. Protein descriptions made using UniProt database information46.