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. 2023 Feb 8;14:692. doi: 10.1038/s41467-023-36096-w

Fig. 1. Mitochondria in neurites of HD patient iPSC-neurons exhibit altered morphology and contain enlarged granules of varying size.

Fig. 1

Slices (~1.4 nm thick) through selected regions of representative cryoET tomograms and corresponding segmentations of local features for a Q18, b Q20, c Q53, d Q66, e Q77, and f Q109 human iPSC-neurons. For HD Qn, mitochondria have swollen cristae and contain enlarged granules compared to controls (Q18 & Q20), with Q109 showing the most aberrant phenotype in which many mitochondria show normal, small granules, some show no granules at all and barely any cristae, and some show large granules. Segmentation colors: red: microtubules, yellow: mitochondrial outer double-membranes, dark blue: granules, and cyan: cristae membranes. Scale bars = 100 nm.