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. 2023 Feb 8;14:692. doi: 10.1038/s41467-023-36096-w

Fig. 2. Mitochondria in HD neurites contain enlarged granules composed of tightly packed, heterogeneous densities.

Fig. 2

Z-slices (~1.4 nm thick) through representative cryoET tomograms of a neurite from a a HD iPSC-neuron (Q77) and b a control iPSC-neuron (Q18), and corresponding oblique cutaway-view segmentations of mitochondrial outer double membranes (yellow) and dense, granular densities inside (light blue), with accompanying zoomed-in views of the mitochondrial granules. Scale bars = 100 nm. Segmentation colors: yellow: double membrane, light blue: mitochondrial granules.