Fig. 3. Mitochondria from neurites of HD mouse model neurons exhibit altered morphology and contain enlarged granules of varying size.

Slices (~1.4 nm thick) through selected regions of representative cryoET tomograms and corresponding segmentations of local features for a WT, b BACHD and c dN17 BACHD primary neurons reveal that neuronal mitochondria in HD mice have swollen cristae and contain enlarged granules compared to controls (WT). Segmentation colors are the same as Fig.1. Scale bars = 100 nm.