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The components of the CKD-MBD— 3 organ dysfunctions, 4 endocrine factors and 2 mineral metabolism dysfunctions. Green arrows show direct effects of renal injury/repair on individual syndrome components, dotted arrows indirect effects. Thick gray arrow indicates that each of the endocrine components regulate mineral homeostasis. Blue arrows show effects of FGF23 and αklotho on organ dysfunction.
