Table 3. Multivariable analysis for the risk factors for all-cause mortality during hospitalization.
| Univariate | Multivariable | |||
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| OR (95% CI) | P-value | OR (95% CI) | P-value | |
| Age >70 years | 8.85 (6.31–12.40) | <0.001 | 7.96 (5.05–12.60) | <0.001 |
| Men | 1.20 (0.85–1.70) | 0.30 | 1.02 (0.67–1.55) | 0.92 |
| Body mass index ≥30 kg/m2 | 0.76 (0.47–1.23) | 0.26 | 1.18 (0.65–2.14) | 0.59 |
| D-dimer levels on admission >1.0 µg/mL | 8.41 (5.59–12.70) | <0.001 | 2.90 (1.83–4.59) | <0.001 |
| Hypertension | 3.21 (2.32–4.44) | <0.001 | 1.28 (0.84–1.92) | 0.25 |
| Diabetes mellitus | 1.68 (1.18–2.40) | 0.003 | 0.95 (0.61–1.46) | 0.80 |
| Heart disease | 3.97 (2.71–5.84) | <0.001 | 1.69 (1.03–2.76) | 0.04 |
| Respiratory disease | 1.36 (0.85–2.19) | 0.20 | 0.76 (0.42–1.38) | 0.37 |
| Active cancer | 5.13 (2.71–9.69) | <0.001 | 3.20 (1.44–7.09) | 0.004 |
| History of major bleeding | 2.94 (1.01–8.56) | 0.049 | 1.30 (0.38–4.45) | 0.67 |
| History of VTE | 4.39 (1.23–15.70) | 0.02 | 1.39 (0.25–7.75) | 0.71 |
| Severity of COVID-19 on admission | ||||
| Mild (Reference) | — | — | — | — |
| Moderate (versus Mild) | 5.94 (3.75–9.42) | <0.001 | 3.02 (1.74–5.25) | <0.001 |
| Severe (versus Mild) | 23.80 (14.50–39.00) | <0.001 | 13.20 (6.72–26.10) | <0.001 |
| Pharmacological thromboprophylaxis | 6.75 (4.46–10.20) | <0.001 | 1.46 (0.86–2.50) | 0.16 |
| Development of thrombosis during hospitalization | 5.75 (3.02–11.00) | <0.001 | 1.77 (0.78–3.99) | 0.17 |
| Development of major bleeding during hospitalization | 10.60 (5.98–18.70) | <0.001 | 2.44 (1.17–5.05) | 0.02 |
CI, confidence interval; COVID-19, novel coronavirus disease 2019; OR, odds ratio; VTE, venous thromboembolism.
Adjusted for age >70 years, male sex, body mass index >30 kg/m2, D-dimer values on admission >1.0 µg/mL, hypertension, diabetes mellitus, heart disease, respiratory disease, active cancer, history of major bleeding, history of VTE, and moderate and high COVID-19 severity at admission.