TABLE 2.

Imaging manifestations of MMA.

Early-onset MMA	From a whole point of view	The volume of white matter decreased, the sulci of cerebrum and cerebellum deepened, and the cortex atrophied
	From a local point of view	Myelination retardation or dysplasia	The white matter was isointense or hypointense on T 1WI and hyperintense on T 2WI and T 2 FLAIR. The white matter was distributed around the lateral ventricle, partly confined to the lateral ventricle triangle or the posterior part of the semioval center, and distributed symmetrically on both sides
		Corpus callosum	In addition to thinning, hyperintensity was also observed on T 2WI
		Globus pallidus	Acute phase	Symmetrical hypointensity on T1WI, hyperintensity on T2WI and T2FLAIR, hyperintensity on DWI and ADC were observed
			Dynamic follow-up	The volume of globus pallidus increased in the early stage and decreased in the late stage, and finally showed cerebrospinal fluid signal intensity, which was hypointensity on T1WI, hyperintensity on T2WI and hypointensity on T2FLAIR
Late-onset MMA	In addition to that above manifestation, late onset MMA also includes spinal cord atrophy and other abnormal change. Its pathological changes are mainly characterized by multifocal demyelination in the brain and spinal cord, which is isointense or hypointense on T1WI and hyperintense on T2WI and T2 FLAIR