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. 2021 Dec 28;54(1):137–147. doi: 10.3724/abbs.2021014

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© The Author(s) 2021.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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S100A6 is a target of miR-493-5p(A) S100A6-targeting miRNAs obtained by intersecting the miRNAs predicted by Starbase and the down-regulated miRNAs identified based on GSE28423. (B) The expression profile of miR-493-5p based on the GSE28423 dataset. (C) The correlation between S100A6 and miR-493-5p in osteosarcoma tissues. (D) Relationship between S100A6 and miR-493-5p expression was confirmed by the dual-luciferase assay. (E) The protein and mRNA expression levels of S100A6 in osteosarcoma cells after transfection with miR-493-5p mimics or inhibitors. *P<0.05 and **P<0.01.