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. 2021 Dec 28;54(1):137–147. doi: 10.3724/abbs.2021014

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© The Author(s) 2021.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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SNHG1 acts as a competing ceRNA of miR-493-5p to regulate the expression of S100A6(A) miR-493-5p-regulating lncRNAs predicted by Starbase and lnc2cancer. (B) The correlation between SNHG1 and miR-493-5p in osteosarcoma tissues. (C) Relationship between SNHG1 and miR-493-5p expression was confirmed by the dual-luciferase assay. (D) Correlation of SNHG1 and miR-493-5p with Ago2 was predicted by the RIP assay. The expressions of SNHG1, miR-493-5p (E), and S100A6 (F) in MG63 cells after transfection with blank vectors or SNHG1-overexpressing vectors, and in 143B cells after transfection of si- SNHG1 (si-SNHG1-1 and si-SNHG1-2) or si-NC. *P<0.05 and **P<0.01.