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. 2021 Dec 28;54(1):137–147. doi: 10.3724/abbs.2021014

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© The Author(s) 2021.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Silencing of S100A6 reverses the effect of SNHG1 overexpression on cell proliferation and osteogenic differentiation in osteosarcoma cells MG63 cells were respectively transfected with blank vectors, SNHG1-overexpressing vectors, and the combination of SNHG1-overexpressing vectors with si-NC or si-S100A6-1.

(A) The colonies formed by MG63 cells after different transfection. (B) EdU staining of MG63 cells after different transfection. (C,D) S100A6, OPN and OCN expressions, (E) matrix mineralization, (F) ALP staining and ALP activity of transfected MG63 cells after being cultured in the osteogenic induction medium for 14 days. *P<0.05.