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. 2021 Dec 23;54(2):220–231. doi: 10.3724/abbs.2021023

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© The Author(s) 2021.

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/).

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Diagram of the function of CPT1A in ccRCC progression(A) ccRCC cells have an excessive lipid accumulation caused by CPT1A deficiency. CPT1A deficiency inhibits PPARα level and promotes CD36 level, leading to an increased lipid accumulation which in turn promotes an activity of PI3K/Akt signaling. (B) Overexpression of CPT1A promotes ccRCC cell apoptosis by suppressing the activity of PI3K/Akt signaling and decreasing intracellular lipid accumulation. Mechanistically, CPT1A overexpression downregulates the expressions of CD36 and SRB1, and upregulates the expression of PPARα.