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. 2021 Dec 28;54(1):77–90. doi: 10.3724/abbs.2021012

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© The Author(s) 2021.

This is an open access article under the Creative Commons Attribution License, which permits use, sharing, adaptation, distribution, and reproduction with appropriate credit to the original author(s). For details of the license, please visit http://creativecommons.org/licenses/by/4.0/.

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Knockdown of MEF2C reduced the level of synapse-associated proteins in SH-SY5Y cells treated with AβO(A) The protein level of PSD95 in cells was detected by western blot analysis. (B) The protein level of SYN in cells weas detected by western blot analysis. SH-SY5Y cells were transfected with GV248-shRNA-NC (GV248-shRNA-NC) or GV248-shRNA-Mef2c (GV248-shRNA-Mef2c). SH-SY5Y cells were transfected with GV248-shRNA-NC and exposed to AβO (GV248-shRNA-NC+Aβ). SH-SY5Y cells were transfected with GV248-shRNA-Mef2c and exposed to AβO (GV248-shRNA-Mef2c+Aβ). Data are presented as the mean±standard deviation. *P<0.05 vs GV248-shRNA-NC; #P<0.05 vs GV248-shRNA-NC+Aβ.