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. 2021 Dec 28;54(1):77–90. doi: 10.3724/abbs.2021012

Figure2 .

Figure2

Knockdown of Mef2c increased the deposition of Aβ in the cortex of APP/PS1 mice(A,B) Immunofluorescence dual labeling of Mef2c and Aβ in the cortex of mice. (C,D) IOD of Mef2c in the cortex of 6- and 10-month-old mice. (E,F) IOD of Aβ in the cortex of 6- and 10-month-old mice. C57 WT mice were injected with Ad-shRNA-NC (WT+Ad-shRNA-NC) or Ad-shRNA-Mef2c (WT+Ad-shRNA-Mef2c). APP/PS1 mice were injected with Ad-shRNA-NC (APP/PS1+Ad-shRNA-NC) or Ad-shRNA-Mef2c (APP/PS1+Ad-shRNA-Mef2c). Red represents a positive result for Aβ, while green represents a positive result for Mef2c. The cell nuclei were stained blue with DAPI in panels A and B. Scale bar, 20 μm. Data are presented as the mean±standard deviation. Ad-shRNA, Ad-shRNA-NC. *P<0.05 vs WT+Ad-shRNA-NC; #P<0.05 vs APP/PS1+Ad-shRNA-NC.