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. 2021 Dec 28;54(1):77–90. doi: 10.3724/abbs.2021012

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© The Author(s) 2021.

This is an open access article under the Creative Commons Attribution License, which permits use, sharing, adaptation, distribution, and reproduction with appropriate credit to the original author(s). For details of the license, please visit http://creativecommons.org/licenses/by/4.0/.

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Knockdown of Mef2c reduced learning and memory abilities of APP/PS1 mice(A,D) Escape latency of 6- and 10-month-old mice. (B,E) Platform stay time of 6- and 10-month-old mice. (C,F) Number of crossing platforms for 6- and 10-month-old mice. C57 WT mice were injected with Ad-shRNA-NC (WT+Ad-shRNA-NC). C57 WT mice were injected with Ad-shRNA-Mef2c (WT+Ad-shRNA-Mef2c). APP/PS1 mice were injected with Ad-shRNA-NC (APP/PS1+Ad-shRNA-NC). APP/PS1 mice were injected with Ad-shRNA-Mef2c (APP/PS1+Ad-shRNA-Mef2c). Data are presented as the mean±standard deviation. *P<0.05 vs WT+Ad-shRNA-NC; #P<0.05 vs APP/PS1+Ad-shRNA-NC.