Skip to main content
. 2021 Dec 28;54(1):77–90. doi: 10.3724/abbs.2021012

Figure4 .


Figure4

Knockdown of Mef2c increased apoptosis in the cortex of APP/PS1 mice(A,B) The level of apoptosis in the cortex of 6- and 10-month-old mice was detected by TUNEL assay. Red represents cells undergoing apoptosis, while blue represents the cell nuclei which were stained with DAPI. (C,F) Apoptosis rate in 6- and 10-month-old mice. (D,G) The level of BAX in the cortex of 6- and 10-month-old mice was detected by western blot analysis. (E,H) The level of BCL-2 in the cortex of 6- and 10-month-old mice was detected by western blot analysis. C57 WT mice were injected with Ad-shRNA-NC (WT+Ad-shRNA-NC) or Ad-shRNA-Mef2c (WT+Ad-shRNA-Mef2c). APP/PS1 mice were injected with Ad-shRNA-NC (APP/PS1+Ad-shRNA-NC) or Ad-shRNA-Mef2c (APP/PS1+Ad-shRNA-Mef2c). Data are presented as the mean±standard deviation. *P<0.05, **P<0.01 vs WT+Ad-shRNA-NC; #P<0.05 vs APP/PS1+Ad-shRNA-NC.