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. 2021 Dec 28;54(1):77–90. doi: 10.3724/abbs.2021012

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© The Author(s) 2021.

This is an open access article under the Creative Commons Attribution License, which permits use, sharing, adaptation, distribution, and reproduction with appropriate credit to the original author(s). For details of the license, please visit http://creativecommons.org/licenses/by/4.0/.

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Knockdown of MEF2C increased apoptosis in SH-SY5Y cells treated with AβO(A) The level of apoptosis in cells was detected by flow cytometry. (B) Apoptosis rate in each group of cells. (C) The protein level of BAX in cells was detected by western blot analysis. (D) The protein level of BCL-2 in cells was detected by western blot anaysis. SH-SY5Y cells were transfected with GV248-shRNA-NC (GV248-shRNA-NC) or GV248-shRNA-Mef2c (GV248-shRNA-Mef2c). SH-SY5Y cells were transfected with GV248-shRNA-NC and exposed to AβO (GV248-shRNA-NC+Aβ). SH-SY5Y cells were transfected with GV248-shRNA-Mef2c and exposed to AβO (GV248-shRNA-Mef2c+Aβ). Data are presented as the mean±standard deviation. *P<0.05, **P<0.01 vs GV248-shRNA-NC; #P<0.05, ##P<0.01 vs GV248-shRNA-NC+Aβ.