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. 2021 Dec 28;54(1):77–90. doi: 10.3724/abbs.2021012

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© The Author(s) 2021.

This is an open access article under the Creative Commons Attribution License, which permits use, sharing, adaptation, distribution, and reproduction with appropriate credit to the original author(s). For details of the license, please visit http://creativecommons.org/licenses/by/4.0/.

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Knockdown of Mef2c in the cortex of APP/PS1 mice increased the expression of BACE1 and decreased the expression of BACE2(A,C) The level of BACE1 in the cortex of 6- and 10-month-old mice was detected by western blot analysis. (B,D) The level of BACE2 in the cortex of 6- and 10-month-old mice was detected by western blot analysis. C57 WT mice were injected with Ad-shRNA-NC (WT+Ad-shRNA-NC) or Ad-shRNA-Mef2c (WT+Ad-shRNA-Mef2c). APP/PS1 mice were injected with Ad-shRNA-NC (APP/PS1+Ad-shRNA-NC) or Ad-shRNA-Mef2c (APP/PS1+Ad-shRNA-Mef2c). Data are presented as the mean ± standard deviation. *P<0.05 vs WT+Ad-shRNA-NC; #P<0.05 vs APP/PS1+Ad-shRNA-NC.