Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Dec 28;54(1):77–90. doi: 10.3724/abbs.2021012

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021.

This is an open access article under the Creative Commons Attribution License, which permits use, sharing, adaptation, distribution, and reproduction with appropriate credit to the original author(s). For details of the license, please visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Knockdown of Mef2c reduced the expression of Nrf2-antioxidant response element pathway-related proteins in the cortex of APP/PS1 mice(A,E) The level of Nrf2 in the cortex of 6- and 10-month-old mice was detected by western blot anlaysis. (B,F) The level of heme oxygenase 1 in the cortex of 6- and 10-month-old mice was detected by western blot analysis. (C,G) The level of superoxide dismutase 2 in the cortex of 6- and 10-month-old mice was detected by western blot analysis. (D,H) The level of NADPH quinone dehydrogenase 1 in the cortex of 6- and 10-month-old mice was detected by western blot analysis. C57 WT mice were injected with Ad-shRNA-NC (WT+Ad-shRNA-NC) or Ad-shRNA-Mef2c (WT+Ad-shRNA-Mef2c). APP/PS1 mice were injected with Ad-shRNA-NC (APP/PS1+Ad-shRNA-NC) or Ad-shRNA-Mef2c (APP/PS1+Ad-shRNA-Mef2c). Data are presented as the mean±standard deviation. *P<0.05 vs WT+Ad-shRNA-NC; #P<0.05 vs APP/PS1+Ad-shRNA-NC.