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. 2021 Dec 2;54(1):25–36. doi: 10.3724/abbs.2021003

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© The Author(s) 2021.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/).

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DNA recognition of MerR-family TFs(A) The consensus DNA sequence logo of E. coli CueR regulated promoters. The palindromic repeats are highlighted by arrows. The positions are numbered respective to the transcription start site (+1). (B) The interaction between the CueR-DBD and dsDNA. The sequence nonspecific interactions between backbone phosphates of DNA and residues of CueR-DBD are shown in the middle panel. The base-specific interactions made by CueR-DBD are shown in the right panel. (C) The consensus protein sequence logo of CueR from various bacterial species. (D) The multiple-sequence alignment of DBD from multiple MerR TFs. The residues contacting backbone phosphates are labeled by diamonds and the residues making base-specific interactions are labeled by asterisks.