Figure4 .

MiR-665 regulates sorafenib resistance in HCC cells(A,B) CCK-8 assay and EdU analysis were used to determin cell viability and proliferation of HCC cells exposed to sorafenib following miR-665 mimics or inhibitors treatment. **P<0.01 and ***P<0.001. (C) The invasion ability of HCC cells transfected with miR-665 mimics or inhibitors combined with sorafenib was confirmed by Transwell invasion analysis. *P<0.05, **P<0.01, and ***P<0.001. (D) Western blot analysis of FN-1, E-cadherin, Vimentin and Twist 1 levels in HCC cells.