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Interactions of DBDs with different response elements
(A) The typical structure of NR DBD (PDB code: 4CN5). (B–H) Homo- or hetero-dimers of NR DBD complexes with DR0 to DR5 response elements (PDB codes: 4CN5, 1DSZ, 1GA5, 1KB2, 1YNW, 6XWG, and 6XWH, respectively). (I,J) Homodimers of GR and ERα bound to inverted repeats of the half-site sequences (PDB codes: 5CBX, 4AA6). (K,L) NGFI-B and hLRH-1 bound to single half-sites of DNA sequence (PDB codes: 1CIT, 5L0M).
