Figure6 .

Four multi-domain complex structures of NRs

(A) The PPARγ-RXRα (colored in red and blue, respectively) heterodimer on DNA response element with DR1 (PDB code: 3E00). (B) The HNF-4α homodimer bound to DR1 (PDB code: 4IQR). (C) The LXRβ-RXRα (colored in yellow and magenta, respectively) heterodimer on DR4 (PDB code: 4NQA). (D) The RARβ-RXRα (colored in orange and purple, respectively) heterodimer bond to DR1 (PDB code: 5UAN). The key DBD-interacting region at the H9 and H10 of LBD is marked with capital letters.