Table 4.
The frequency of carrying at least one of the HLA-DRB1*03/X genotypes in patients grouped according to presence or absence of at least one of the investigated autoantibody classes and low or normal plasma MBL levels.
| HLA-DRB1 genotype | 0 AB | ≥1 AB | ||||
|---|---|---|---|---|---|---|
| MBL ≤500 µg/l Ntotal = 35 N (%) |
MBL >500 µg/l Ntotal = 60 N (%) |
Pa | MBL ≤500 µg/l Ntotal = 22 N (%) |
MBL >500 µg/l Ntotal = 17 N (%) |
Pb | |
| 01/03 | 5 (14.3) | 8 (13.3) | 1.0 | 4 (18.2) | 1 (5.9) | 0.36 |
| 03/03 | 3 (8.6) | 4 (6.7) | 1.0 | 1 (4.5) | 1 (5.9) | 1.0 |
| 03/04 | 7 (20.0) | 12 (20.0) | 1.0 | 1 (4.5) | 4 (23.5) | 0.15 |
| 03/07 | 5 (14.3) | 8 (13.3) | 1.0 | 3 (13.6) | 0 (0.0) | 0.24 |
| 03/08 | 1 (2.9) | 0 (0.0) | 0.37 | 2 (9.1) | 3 (17.6) | 0.64 |
| 03/09 | 1 (2.9) | 3 (5.0) | 1.0 | 0 (0.0) | 0 (0.0) | – |
| 03/10 | 0 (0.0) | 0 (0.0) | – | 0 (0.0) | 0 (0.0) | – |
| 03/11 or 03/12 | 3 (8.6) | 5 (8.3) | 1.0 | 2 (9.1) | 2 (11.8) | 1.0 |
| 03/13 | 5 (14.3) | 9 (15.0) | 1.0 | 2 (9.1) | 1 (5.9) | 1.0 |
| 03/14 | 0 (0.0) | 2 (3.3) | 0.53 | 2 (9.1) | 1 (5.9) | 1.0 |
| 03/15 | 4 (11.4)* | 8 (13.3)* | 1.0 | 5 (22.7)* | 4 (23.5)* | 1.0 |
| 03/16 | 1 (2.9) | 1 (1.7) | 1.0 | 0 (0.0) | 0 (0.0) | – |
AB, antibody; MBL, mannose-binding lectin a,b Comparing patients with low or normal p-MBL; *, comparing patients without autoantibodies with genotype HLA-DRB1*03/15 versus patients with autoantibodies without the genotype, p = 0.13.