Figure 3.

The microscopic pathological structure of tumor tissue. (A) The tumor was mainly located in the submucosa of the gallbladder (black arrow). (B) The white arrow shows normal liver tissue and the black arrow shows paragangliomas of the gallbladder tissue, in which tumor cells were diffusely distributed in clusters. (C) The gallbladder wall, which is surrounded by tumor cells, was covered with simple columnar epithelium structures (black arrow). (D) The paraganglioma demonstrated a characteristic zellballen architecture, rich in pink sinusoids inside (black arrow). Parts E and F show the junction structure of the tumor with adjacent liver tissues, and normal liver tissues all expressed the epithelial-derived markers Hepatocyto and CK-pan (white arrows), while non-epithelial paraganglioma tissue was negative (black arrows), which also indicated some degree of tumor invasion of the liver tissue.