Table 2. Lesion level quantitative and qualitative OCT analysis results of patients with and without TCFA.
| Variables | FFR(–)/TCFA(+) n=104a | FFR(–)/TCFA(–) n=341 | p-value |
|---|---|---|---|
| Quantitative OCT analysis | |||
| MLA (IQR), mm2 | 2.35 (1.70-3.18) | 2.60 (1.90-3.50) | 0.09 |
| % area stenosis (IQR), % | 65 (57-73) | 62 (53-70) | 0.07 |
| Lesion length (IQR), mm | 27.65 (18.10-36.10) | 20.10 (14.10-29.60) | <0.001 |
| Proximal RLD (IQR), mm | 3.10 (2.70-3.50) | 3.00 (2.60-3.50) | 0.63 |
| Distal RLD (IQR), mm | 2.50 (2.30-3.00) | 2.60 (2.20-3.00) | 0.68 |
| Qualitative OCT analysis | |||
| Fibrous cap thickness (IQR), μm | 60 (56-63) | 151 (109-218) | - |
| Calcification present, n (%) | 91 (87.5) | 292 (85.6) | 0.99 |
| Calcium arc (IQR), o | 112 (80-192) | 159 (88-244) | 0.02 |
| Calcified noduli, n (%) | 36 (34.6) | 157 (46.0) | 0.04 |
| Cholesterol clefts, n (%) | 75 (72.8) | 149 (44.1) | <0.001 |
| Lipidic plaque, n (%) | 104 (100) | 201 (58.9) | <0.001 |
| Lipidic arc (IQR), o | 241 (193-287) | 169 (126-214) | <0.001 |
| Healed plaque, n (%) | 25 (24.0) | 64 (18.9) | 0.26 |
| Neovascularisation, n (%) | 88 (84.6) | 232 (68.0) | 0.002 |
|
Macrophage infiltration, n (%) |
72 (69.9) | 157 (46.0) | <0.001 |
| aNumber represents only TCFA hosting lesions. FFR: fractional flow reserve; IQR: interquartile range; MLA: minimal lumen area; OCT: optical coherence tomography; RLD: reference lumen diameter; TCFA: thin-cap fibroatheroma | |||