Table 5.
Univariate and multivariate Cox-analyses of prognostic factors for overall survival in metastatic PDAC patients.
| Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% | p-Value | HR | 95% | p-Value | |
| Age(years) | ||||||
| <50 | 1 | 1 | ||||
| 50 ~ 64 | 1.25 | 1.04-1.49 | 0.02 | 1.14 | 0.95-1.36 | 0.17 |
| ≥65 | 1.58 | 1.32-1.88 | <0.001 | 1.35 | 1.12-1.61 | 0.001 |
| Sex | ||||||
| Male | 1 | |||||
| Female | 0.98 | 0.91-1.06 | 0.65 | |||
| Race | ||||||
| White | 1 | 1 | ||||
| Black | 1.15 | 1.03-1.28 | 0.02 | 1.11 | 0.99-1.24 | 0.07 |
| Other | 0.98 | 0.85-1.13 | 0.79 | 0.91 | 0.79-1.05 | 0.20 |
| Tumor location | ||||||
| Head | 1 | 1 | ||||
| Body/tail | 1.11 | 1.02-1.20 | 0.02 | 1.10 | 1.01-1.20 | 0.02 |
| Other | 1.11 | 0.99-1.26 | 0.08 | 1.08 | 0.95-1.21 | 0.23 |
| Grade | ||||||
| I-II | 1 | 1 | ||||
| III-IV | 1.31 | 1.21-1.41 | <0.001 | 1.37 | 1.26- 1.48 | <0.001 |
| T stage | ||||||
| T1 | 1 | 1 | ||||
| T2 | 1.30 | 1.03-1.64 | 0.03 | 1.27 | 1.01-1.61 | 0.05 |
| T3 | 0.95 | 0.76- 1.20 | 0.68 | 1.08 | 0.85-1.36 | 0.51 |
| T4 | 1.14 | 0.90-1.44 | 0.29 | 1.18 | 0.93-1.49 | 0.17 |
| Surgery | ||||||
| No | 1 | 1 | ||||
| Yes | 0.51 | 0.44-0.58 | <0.001 | 0.52 | 0.46-0.60 | <0.001 |
| Chemotherapy | ||||||
| No/Unknown | 1 | 1 | ||||
| Yes | 0.35 | 0.32-0.38 | <0.001 | 0.33 | 0.31-0.36 | <0.001 |
| Number of sites of metastases | ||||||
| 1 | 1 | 1 | ||||
| >1 | 1.36 | 1.23- 1.51 | <0.001 | 1.31 | 1.18-1.45 | <0.001 |
For race, ‘other’ includes American Indian, AK Native, Asian, and Pacific Islander. For tumor location, ‘other’ includes overlapping lesion of pancreas, pancreatic duct, and other specified parts of pancreas.