Table 1. Characteristics of Participants at ARIC Study Visit 4 According to Past Change in NT-proBNP.
| Characteristic | Mean (SD)a | P value | ||||
|---|---|---|---|---|---|---|
| Total (N = 9776) | Visit 2 <125 pg/mL | Visit 2 ≥125 pg/mL | ||||
| Visit 4 <125 pg/mL (n = 6693) | Visit 4 ≥125 pg/mL (n = 1744) | Visit 4 <125 pg/mL (n = 320) | Visit 4 ≥125 pg/mL (n = 1019) | |||
| Age, y | 62.6 (5.7) | 61.8 (5.4) | 64.2 (5.6) | 62.6 (5.5) | 65.3 (5.7) | <.001 |
| Women, No. (%) | 5523 (56.5) | 3453 (51.6) | 1088 (62.4) | 247 (77.2) | 731 (71.7) | <.001 |
| Men, No. (%) | 4253 (43.5) | 3240 (48.4) | 655 (37.6) | 73 (22.8) | 288 (28.3) | |
| Black, No. (%) | 2082 (21.3) | 1606 (24.0) | 260 (14.9) | 69 (21.6) | 145 (14.2) | <.001 |
| White, No. (%) | 7694 (78.7) | 5087 (76.0) | 1484 (85.1) | 251 (78.4) | 874 (85.8) | |
| Hypertension, No. (%) | 4458 (45.6) | 2704 (40.4) | 991 (56.8) | 170 (53.0) | 598 (58.7) | <.001 |
| Hypertension medication, No. (%) | 3353 (34.3) | 2035 (30.4) | 715 (41.0) | 142 (44.4) | 470 (46.1) | <.001 |
| Blood pressure, mm Hg | ||||||
| Systolic | 128.3 (20.1) | 126.4 (18.7) | 133.3 (21.8) | 126.8 (22.4) | 132.87 (22.7) | <.001 |
| Diastolic | 70.0 (9.9) | 70.2 (9.6) | 70.1 (10.6) | 68.8 (10.3) | 69.0 (10.7) | .04 |
| LDL-C, mg/dL | 123.0 (33.3) | 124.8 (33.0) | 118.8 (32.8) | 123.2 (33.6) | 117.7 (34.7) | <.001 |
| Triglycerides, mg/dL | 62.4 (37.9) | 62.9 (38.9) | 62.4 (35.8) | 62.2 (42.1) | 59.3 (32.4) | .04 |
| Cholesterol-lowering medication, No. (%) | 1339 (13.7) | 863 (12.9) | 270 (15.5) | 41 (12.9) | 167 (16.4) | .001 |
| Diabetes, No. (%) | 1506 (15.4) | 1084 (16.2) | 263 (15.1) | 46 (14.5) | 114 (11.2) | .001 |
| Blood glucose, mg/dL | 1980.2 (663.1) | 2012.6 (699.1) | 1922.5 (591.0) | 1958.6 (652.3) | 1873.9 (499.1) | <.001 |
| Body mass indexb | 28.7 (5.5) | 28.9 (5.3) | 28.3 (5.6) | 28.8 (6.0) | 27.4 (5.8) | <.001 |
| eGFR, mL/min/1.73m2 | 86.1 (16.3) | 88.5 (15.1) | 81.7 (17.1) | 83.6 (15.7) | 78.4 (18.4) | <.001 |
| Current smoking, No. (%) | 1408 (14.4) | 910 (13.6) | 277 (15.9) | 60 (18.6) | 164 (16.1) | .003 |
| Prevalent coronary heart disease, No. (%) | 694 (7.1) | 315 (4.7) | 188 (10.8) | 23 (7.3) | 166 (16.3) | <.001 |
Abbreviations: ARIC, Atherosclerosis Risk in Communities; eGFR, estimated glomerular filtration rate; LDL-C, low-density lipoprotein cholesterol; NT-proBNP, N-terminal pro–B-type natriuretic peptide.
SI conversion factors: To convert cholesterol to millimoles per liter, multiply by 0.0259; glucose to millimoles per liter, multiply by 0.0555; NT-proBNP to nanograms per liter, multiply by 1; triglycerides to millimoles per liter, multiply by 0.0113.
a
Continuous variables expressed as means (SDs) and compared using analysis of variance. Categorical variable expressed as percentages and compared using χ2 test.
b
Body mass index is calculated as weight in kilograms divided by height in meters squared.