Table 2. Association of Serial N-Terminal Pro–B-Type Natriuretic Peptide (NT-proBNP) Measurements and Risk of Incident Heart Failure Hospitalization and All-Cause Death Over a Median Follow-up of 19.7 Years.
| Factor | Visit 2 <125 pg/mL | Visit 2 ≥125 pg/mL | ||
|---|---|---|---|---|
| Visit 4 <125 pg/mL (n = 6726) | Visit 4 ≥125 pg/mL (n = 1747) | Visit 4 <125 pg/mL (n = 321) | Visit 4 ≥125 pg/mL (n = 1022) | |
| Incident heart failure hospitalization | ||||
| No. | 1114 | 530 | 81 | 363 |
| Incidence rate per 1000 person-years | 9.5 | 20.5 | 14.6 | 25.5 |
| Model 1a | 1 [Reference] | 2.29 (2.06-2.54) | 1.56 (1.24-1.95) | 2.90 (2.57-3.26) |
| Model 2b | 1 [Reference] | 1.86 (1.60-2.16) | 1.01 (0.71-1.43) | 2.40 (2.00-2.88) |
| All-cause death | ||||
| No. | 2663 | 1025 | 149 | 656 |
| Incidence rate per 1000 person-years | 21.4 | 35.7 | 25.6 | 41.4 |
| Model 1a | 1 [Reference] | 1.77 (1.65-1.90) | 1.20 (1.02-1.42) | 2.10 (1.93-2.29) |
| Model 2b | 1 [Reference] | 1.32 (1.19-1.47) | 0.79 (0.61-1.01) | 1.68 (1.47-1.91) |
SI conversion factors: To convert NT-proBNP to nanograms per liter, multiply by 1.
a
Model 1: age, sex, and race. Multivariable-adjusted hazard ratios (95% CIs) are reported.
b
Model 2: model 1 plus systolic blood pressure, diastolic blood pressure, hypertensive medication use, diabetes, fasting glucose, low-density lipoprotein cholesterol, triglycerides, cholesterol-lowering medication use, cigarette smoking, estimated glomerular filtration rate, body mass index, and prevalent coronary heart disease. Multivariable-adjusted hazard ratios (95% CIs) are reported.