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. 2022 Feb 12;14:100214. doi: 10.1016/j.mtadv.2022.100214

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Fig. 4 — In vivo antitumor efficacy in K7 osteosarcoma-allografted mice with an initial tumor volume of 200 mm³. (a) Experimental schedule for tumor induction and drug treatments. (b) Tumor volumes, (c) tumor inhibition rates, (d) body weight changes, and (e) survival rates of mice treated with PBS as a control, free DOX, HA-DOX, or HA-DOX/CaCO3. Scale bar: 1.0 cm. The statistical data are presented as mean ± standard deviation (n = 8 for (b)–(d); and n = 6 for (e). ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001). Adapted with permission from Ref. [81]. Copyright © 2018, SpringerNature.